Šta je Carvaxyl?

Kako antibiotici sve više gube dejstvo zbog neadekvatne upotrebe i pojave rezistencije, tražeći alternativu za njih,  počelo se sa istraživanjem ulja origana, koji se tradicionalno koristio u zemljama Mediterana za razne vrste infekcija, prvenstveno respiratorne, ali i za razne vrste oboljenja kože. Institut North American Herb and Spice se godinama bavio istraživanjem svih sorti origana dok se nije došlo do Oreganol P73 formule ulja origana. Zahvaljujući ovoj formuli Carvaxyl je najpotentnije ulje divljeg origana sa visokim koncentracijama preko 50 aktivnih supstanci.

Naučna istraživanja

Naučna istraživanja

Kako deluje Carvaxyl?

Klinička ispitivanja Oreganol P73 formule ulja origana su započeta 2001 godine, na Džordžtaun Univerzitetu u Vašingtonu. Od tada je urađen veliki broj studija kojima je potvrđeno da Carvaxyl deluje antimikrobno, antizapaljenski i antioksidantno.

 

Antimikrobno dejstvo – inhibira rast i razmnožavanje preko 30 vrsta mikroorganizama (bakterija, virusa, parazita i gljivica). Antibakterijsko dejstvo ostvaruje zbog sposobnosti da penetrira ćelijsku membranu i naruši njen integritet. Studije su pokazale da kada bakterijska ćelija dođe u kontakt sa uljem od origana, sadržaj bakterije iscuri napolje, PH unutar bakterije postaje kiseo, čime se ugrožava njen metabolizam i sposobnost replikacije.*2

Antinflamatorno dejstvo – sadrži supstancu Beta- Caryophyllin koja inhibira zapaljenje*3 pa se pokazalo efikasnim kod sezonskih alergija, reumatoidnog artritisa,bronhitisa, upale desni, bolova u mišićima, psorijaze, seboreje i rozacee.

Antioksidativno dejstvo – štiti ćelije od dejstva slobodnih radikala koji oštećuju ćelije i smatraju se jednim od glavnih uzročnika zapaljenskih bolesti, ateroskleroze, kardiovaskularnih i malignih bolesti. *3,4

REFERENCE

1 Effects of Essential Oils and Monolaurin on Staphylococcus aureus: In Vitro and In Vivo Studies  Vijaya Manohar,1 Cass Ingram,2 Judy Gray,2 Nadeem A. Talpur,1 Bobby W. Echard,1 Debasis Bagchi3 and Harry G. Preuss1 1Department of Physiology and Biophysics, GeorgetownUniversity Medical Center, Washington, DC; 2North American Herbs and Spices, Waukeegan, IL; 3Department of Pharmacy Sciences, Creighton University School of Pharmacy and AHP, Omaha, NE, USA, 2001

2A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. Lambert RJ, Skandamis PN, Coote PJ, Nychas GJ. J Appl Microbiol. 2001 Sep;91(3):453-62.

3Antiiflamatory and anti-allergy efects of RA, inhibition of seasonal allergic rhinosinusitis and its mechanisam, Osakabe N. Biofactors 21 (1-4): 127-131; 2004

4Antioxidant activity and phenolic compounds in selected herbs, Zhang XL1, Guo YS1, Wang CH1, Li GQ1 Food Chem 49(11):5165-70, 2001

5Minimum Inhibitory Concentrations of Herbal Essential Oils and Monolaurin for Gram-Positive and Gram-Negative Bacteria,Harry G. Preuss, Bobby Echard, Mary Enig, Itzhak Brook,cThomas B. Elliott,

Department of Physiology and Biophysics, Georgetown University Medical Center,Washington, DC 20057; Enig Associates, Silver Spring, MD 20904; Armed Forces, Radiobiology Research Institute, Bethesda, MD 20889

6In Vitro Antibacterial Activity of Essential Oils against Streptococcus pyogenes

Julien Sfeir, 1 Corinne Lefrançois, 1 , 2 Dominique Baudoux, 3 Séverine Derbré, 4 ,* and Patricia Licznar 1 Evid Based Complement Alternat Med. 2013; 2013: 269161.  Published online 2013 Apr 11. doi:  10.1155/2013/269161 PMCID: PMC3638616

7Virucidal Eectivness test, Coronavirus,M. Khalid Ijaz, DVM, Ph.D. MICROBIOTEST, INC. 105B Carpenter Drive Sterling, Virginia 20164 LIN 514-101

8Phenolic compounds from Origanum vulgare and their antioxidant and antiviral activities.Zhang XL1, Guo YS1, Wang CH1, Li GQ1, Xu JJ1, Chung HY2, Ye WC1, Li YL3, Wang GC4. Food Chem. 2014;152:300-6. doi: 10.1016/j.foodchem.2013.11.153. Epub 2013 Dec 1.

9The antibacterial activity of oregano essential oil (Origanum heracleoticum L.) against clinical strains of Escherichia coli and Pseudomonas aeruginosa; Sienkiewicz M1, Wasiela M, Głowacka A. Med Dosw Mikrobiol. 2012;64(4):297-307.

10Chemical compositions and antibacterial effects of essential oils of Turkish oregano (Origanum minutiflorum), bay laurel (Laurus nobilis), Spanish lavender (Lavandula stoechas L.), and fennel (Foeniculum vulgare) on common foodborne pathogens. Dadalioglu I1, Evrendilek GA.2004

11Antifungal activities of origanum oil against Candida albicans

Vijaya Manohar,1 Cass Ingram,2 Judy Gray,2 Nadeem A. Talpur,1 Bobby W. Echard,1 Debasis Bagchi3 and Harry G. Preuss1 1Department of Physiology and Biophysics, GeorgetownUniversity Medical Center, Washington, DC; 2North American Herbs and Spices, Waukeegan, IL; 3Department of Pharmacy Sciences, Creighton University School of Pharmacy and AHP, Omaha, NE, USA, 2001

12Oregano kills Giardia intestinalis trophozoites in vitro: antigiardiasic activity and ultrastructural damage.Ponce-Macotela M1, Rufino-González Y, González-Maciel A, Reynoso-Robles R, Martínez-Gordillo MN. Parasitol Res. 2006 May;98(6):557-60. Epub 2006 Jan 20.

13Inhibition of enteric parasites by emulsified oil of oregano in vivo.

Force M1, Sparks WS, Ronzio RA. Phytother Res. 2000 May;14(3):213-4.